Efeitos do uso crônico de estanozolol e do treinamento físico sobre a morfofisiologia cardiovascular, renal, hepática, estresse oxidativo e comportamento em ratos

Abstract

Every decade, indiscriminate use of stanozolol has been increasing in gyms, as it promotes increased strength without extra weight gain, does not convert to estrogen, does not cause excess water retention, and helps with fat loss while preserving mass muscle. However, indiscriminate use without a prescription can cause cardiovascular complications, liver dysfunction, kidney damage, psychiatric disorders, thyroid reduction and infertility. We aimed to investigate the effects of stanozolol on systolic pressure, renal, hepatic and behavioral parameters in sedentary and trained rats, in addition to describing the profile of bodybuilding practitioners in Pernambuco who use steroids (EAA). Considering that the literature only addresses physical activities. For this purpose, 40 animals were selected, aged 90 days and divided into four groups: vehicle control group (n=5) that received saline solution, intramuscularly and the stanozolol control group (n=5) in which stanozolol was administered, control group trained (n=5) received saline solution, intramuscularly and trained swimming, trained group stanozolol (n=5) received intramuscular stanozolol and trained swimming. Stanozolol showed significant increases in arterial pressure and oxidative stress. In addition to promoting behavioral changes among rats that grew up together, resulting in increased aggression during and after steroid use. 30.2% of the sample consisted of AAS users. The use of stanozolol compromises the cardiovascular, renal and hepatic systems and promotes an increase in aggressive behavior at high doses. Something that needs to be worked around, in view of the negative impact on health, when not properly prescribed.