Viabilidade do protocolo de contenção farmacológica com dextrocetamina associada ao midazolam, por via intramuscular, para avaliação oftálmica em felinos

Abstract

Sedation, as well as chemical restraint, is extremely important in Veterinary Ophthalmology, and it is very common to care for non-cooperative animals in the routine of feline ophthalmologists. It is believed that severe eye pain may act as a detrimental factor when performing a complete eye examination. For these reasons, the need to understand the effects of dissociative anesthetic agents, under the feline eye system, specifically on intraocular pressure, is of paramount importance. The objective of this study was to evaluate the effects the chemical restraint promoted by the use of dextrocetamine in combination with midazolam, intramuscularly, under intraocular pressure in healthy cats, treated at the Hospital Veterinary University (HVU), from the Federal University of Agreste of Pernambuco (UFAPE), tutored by the Rural Federal University of Pernambuco (UFRPE). The prospective study included 13 felines selected from the HVU care routine, which comprised the two experimental moments, both the T0 (pre-sedation) and the T10 (post-sedation) moment, where heart rate measurements were made ( HR), respiratory rate (RR), systolic arterial pressure (SAP) and intraocular pressure (IOP) of each patient at both times. All experimental groups were subjected to the Shapiro Wilk´s test in order to indicate whether the groups have a normal distribution, and from these data, and the statistical analysis of the data was performed using the version of the Stats Tester application, developed for Android Operating System. The results obtained in this study for mean intraocular pressure at T0 was 17.34 ± 3.09 mmHg and for T10 it was 17.80 ± 3.04, where no statistically significant difference was observed in the comparison between the moments studied. It is concluded that the combination of dextrocetamine and midazolam can be considered as a chemical containment protocol for non-cooperative patients in routine ophthalmic clinical evaluations for the species under study.