Avaliação clínico-laboratorial de cães naturalmente infectados por Leishmania infantum submetidos a terapia com marbofloxacina associada ao alopurinol

Abstract

In the New World, Leishmania infantum is the agent of visceral leishmaniasis and CanL, which are spread by the bite of infected sand flies. The dog is considered the main reservoir in urban areas of Brazil and the treatment of CanL still represents a challenge. The objective of this study was to evaluate the clinical and laboratory aspects of dogs naturally infected with L. infantum submitted to therapy with marbofloxacin associated with allopurinol. To evaluate the efficacy of marbofloxacin 12 domiciled dogs of both genders, varied race and age between 1-7 years were used. The animals were divided into two treatment groups: Group 1 (G1) were treated with oral marbofloxacin (Marbopet® Laboratory CEVA, Brazil) at 2 mg/Kg/day for 28 days in combination with oral allopurinol at 10 mg/kg every 12 hours and Group 2 (G2) treated with marbofloxacin and allopurinol in the same dosage, but the allopurinol was give to dogs from G2 after 28 days of administration of marbofloxacin. After the treatment dogs were assessed during 90 days by performing monthly physical exams, and evaluating red blood count, white blood count, alkaline phosphatase, alanine aminotransferase, urea, creatinine, serum protein, albumin and globulin parameters. Each clinical parameter was classified according to its severity on a numerical scale of 0 to 3. In group G1, the reduction in scores was 76.4%, while the G2 group presented a reduction of 54.8%. The averages of albumin were higher at 90 days in the G1 group. No dogs from both of groups presented increase of urea and creatinine. After the following up of 90 days it can be concluded the marbofloxacin and allopurinol treatment in combination at the same time provided a greater remission of clinical signs, improvement in hematological and biochemical profiles and increase of albumin value.