Estresse oxidativo em cães (Canis familiaris) Linnaeus, 1758, naturalmente infectados com Leishmania (Leishmania) infantum chagasi (Cunha e Chagas, 1937) Shaw, 2002, submetidos a tratamento experimental

Abstract

Visceral Canine Leishmaniasis (LVC) is a chronic and systemic infectious disease caused in Brazil by a protozoan of the Leishmania (Leishmania) infantum chagasi species, and is transmitted by blood-sucking insects of the species Lutzomyia longipalpis, on the occasion of blood repellent. It is considered an immunomediated disease due to the characteristic of the parasite. In addition, oxidative stress has been studied as one of the factors involved in the immunopathogenesis of the disease. In this study, the serum levels of Oxygen Reactive Species (EROs) of dogs naturally infected with Leishmania (Leishmania) infantum chagasi at Moment zero (M0), and at Moment three (M3) were evaluated. 63.6% of the animals showed a decrease in serum ERO levels after 3 months of treatment, the dogs in this group also showed visible clinical improvement. In 36.4% of the animals, these ROS levels remained high and the patients did not show clinical improvement.