Reações de ciclo-oxidação de derivados nitrogenados do Lapachol - aminação alílica utilizando complexos de paládio (II) catalítico

Abstract

In the course of 1,4-naphthoquinone nucleus studies, was performed the palladium catalyzed allylic oxidation procedure to obtain a heterociclic ring containing nitrogen. Some new compounds were found during the course of these studies, including an improvement in the nor-lapachol condensation reaction between lausone and isobutyraldehyde. A new methodology was also developed to obtain naphthoquinone dimers, with the synthesis of four new entities. The compounds were tested as inhibitors on human topoisomese I I enzyme and in Artemia salina toxicity tests.