Síndrome de apneia hiponeia obstrutiva do sono e estresse oxidativo em mulheres obesas pós-menopausa

Abstract

Obstructive sleep apnea hypopnea syndrome (OSAHS) and obesity are associated with cardiovascular morbidity and mortality and other physiological and immunological disorders. Both can contribute to excessive production of free radicals associated with impaired cellular antioxidant activity framework can lead to oxidative stress. Thus, we aimed to determine whether OSAHS and obesity are correlated with markers of oxidative stress. We evaluated the production of superoxide and nitric oxide - derived serum in obese postmenopausal women, 11 without OSAHS (G1), 9 with mild OSAHS (G2), and 8 with moderate and severe OSAHS (G3). The groups did not differ among themselves as to the production of stress markers (superoxide: G1 - 20,3 ± 3,6 nmol O2-/1x106 cells vs G2 - 20,9 ± 3,0 nmol O2-/1x106 cells vs G3 -19,9 ± 3,2 nmol O2-/1x106 cells) and (nitrates and nitrites: G1 – 6,0 ± 0,5 μM vs. G2 - 5,7 ± 0.3 μM vs G3 – 5,7 ± 0,3 μM). Superoxide production and nitrite and nitrate was not correlated with the apnea hypopnea index (r = 0,161, p = 0,074 and r = - 0,357, p = 0,385, respectively). According to the results of the present study, we can conclude that, in postmenopausal obese women, the severity of OSA did not correlate with markers of oxidative stress. The presence of co-morbidities untreated and even the location of body fat could exert greater influence on the production of free radicals in this population.