Abordagem fitoquímica, aspectos clínicos, laboratoriais e anatomopatológicos da atividade Indigofera suffruticiosa Mill. (Fabaceae) em caprinos (Capra hircus L., 1758)

Abstract

An experimental study about the activity of Indigofera suffruticosa Mill (Fabaceae), was conducted, by administering doses of 10, 20, 30, and 40g/kg/p.v., of watery extract the of the plant to four goats (Capra hircus L.) and 10g/kg/p.v. of the plant “in natura” to the fifth animal. All the goats were male, with no specific race (NSR), and about one year old. Vegetal specimens were brought from the town of Venturosa, Recife and Passira, in after phytochemical analysis, plant from different sites showed similarities and were positive to indicant, glycosis and also had traces of condensed proanthocyanidins. There was neither manifestations of clinical signs not the ocorrence of any death due to the plant ingestion. A greenish coloration was observed the urinalysis; as well as the increase in density (>1040); discrete presence of protein, blood and bilirubin. By the sedimentoscopy, leucocidin, haematuria, besides the presence of renal, urethral cells, cylinders and calcium and phosphate crystals were verified. By the erythroanalysis discrete microcitic anemia, was exhibited. necroscopy alterations consisted of ascites and discrete renal paleness. Histopathological examination the liver, had swelling tumefaction, and vacuolization of hepatocytes, necrotic areas, dissociation of hepatic cords and destruction of sinusoids, areas of congestion and sinusoidal congestion. In the kidneys, there was tubular lesion, degeneration and necrosis of tubular epithelium, glomerulosclerosis, and reactivity of vascular endothelium. The spleen showed discrete hemossiderosis and testicles had testicular degeneration. The leguminosae Indigofera suffruticosa was hepatotoxic, nephrotoxic and caused testicular degeneration in goat (Capra hircus L., 1758).